UmiWell – UmiWell

NAD reloaded: Hacking bacterial defenses

A bstract.Nicotinamide adenine dinucleotide (NAD) is an essential metabolite, and its depletion serves as a common bacterial immune strategy against bacteriophages (phages). In a recent…

UmiWellDecember 30, 2024

DNA Repair

Single-cell NAD(H) levels predict clonal lymphocyte expansion dynamics

A bstract. Adaptive immunity requires the expansion of high-affinity lymphocytes from a heterogeneous pool. Whereas current models explain this through signal transduction, we hypothesized that…

UmiWellDecember 30, 2024

DNA Repair

Toll/interleukin-1 receptor (TIR) domain-containing proteins have NAD-RNA decapping activity

A bstract. The occurrence of NAD+ as a non-canonical RNA cap has been demonstrated in diverse organisms. TIR domain-containing proteins present in all kingdoms of life…

UmiWellDecember 30, 2024

Cellular Repair DNA Repair

NMNAT2 is a druggable target to drive neuronal NAD production

A bstract. Maintenance of NAD pools is critical for neuronal survival. The capacity to maintain NAD pools declines in neurodegenerative disease. We identify that low…

UmiWellDecember 30, 2024

Post Trans-Protein

The interplay of NAD and hypoxic stress and its relevance for ageing

A bstract. Nicotinamide adenine dinucleotide (NAD) is an essential regulator of cellular metabolism and redox processes. NAD levels and the dynamics of NAD metabolism change…

UmiWellDecember 30, 2024

Post Trans-Protein

NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR

Research on the biology of NAD+ has been gaining momentum, offering many critical insights into the pathogenesis of age-associated functional decline and diseases. Notably, two…

UmiWellMay 18, 2024

Cellular Repair

The Role of NAD+ in Regenerative Medicine

The scientific community now recognizes aging as a modifiable process that can be slowed or even reversed, heralding a new era of cellular regenerative medicine…

UmiWellMay 1, 2024

DNA Repair

NAD+ Boosts Mitochondria and Stem Cells, Extends Lifespan

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Morbi vitae dui et nunc ornare vulputate non fringilla massa.

UmiWellApril 29, 2024

Metabolism

NAD+ Boost Eases Heart Failure via SDR

The study examines the effects of increasing cellular NAD+ levels on heart failure. Cardiac dysfunction was induced in SIRT3-deficient mice and compared with wild-type mice…

UmiWellApril 16, 2024

DNA Repair

Reversible Vascular Aging via NAD+-H2S Disruption

A bstract The study finds that NAD precursors can reverse certain aspects of aging by activating sirtuin deacylases (SIRT1-SIRT7), which also mediate the benefits of…

UmiWellMarch 22, 2024