UmiWell – Page 2

Metabolism

NAD+ homeostasis in health and disease

The conceptual evolution of nicotinamide adenine dinucleotide (NAD+) from being seen as a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and…

UmiWellFebruary 22, 2024

Post Trans-Protein Stress Resistance

NAD+ in aging, metabolism, and neurodegeneration

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UmiWellJanuary 23, 2024

Cellular Repair

NAD+ Precursors and Bile Acid Treat Enteric Dysfunction

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UmiWellJanuary 15, 2024

Stress Resistance

NAD+ in Brain Aging and Neurodegenerative Disorders

Tth NAD+ is a pivotal metabolite involved in cellular bioenergetics, genomic stability, mitochondrial homeostasis, adaptive stress responses, and cell survival. Multiple NAD+-dependent enzymes are involved…

UmiWellJanuary 11, 2024

DNA Repair Post Trans-Protein

Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival

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UmiWellJanuary 10, 2024

Metabolism

NAD+ repletion with niacin counteracts cancer cachexia

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UmiWellJanuary 8, 2024

DNA Repair

NAD+ Precursor Prevents Kidney Injury Inflammation

A bstract Our understanding of how global changes in cellular metabolism contribute to human kidney disease remains incompletely understood. Here we show that nicotinamide adenine…

UmiWellJanuary 8, 2024

Cellular Repair

Trigonelline Boosts Muscle Function and Declines in Aging

A bstract Mitochondrial dysfunction and low NAD+ levels are markers of skeletal muscle aging and sarcopenia. This study links circulating trigonelline, related to nicotinic acid,…

UmiWellJanuary 7, 2024

Post Trans-Protein Stress Resistance

NAD+ Controls New Metabolic Pathways

A bstract. A century after the identification of a coenzymatic activity for NAD+, NAD+ metabolism has come into the spotlight again due to the potential…

UmiWellJanuary 7, 2024

Metabolism

NAD+ Regulates Metabolism and DNA Replication

A bstract The complex interplay of enzymatic processes involving nicotinamide adenine dinucleotide (NAD+) is crucial for the maintenance of metabolic equilibrium and genomic stability. As…

UmiWellNovember 13, 2023