DNA Repair – UmiWell

NAD reloaded: Hacking bacterial defenses

A bstract.Nicotinamide adenine dinucleotide (NAD) is an essential metabolite, and its depletion serves as a common bacterial immune strategy against bacteriophages (phages). In a recent…

UmiWellDecember 30, 2024

DNA Repair

Single-cell NAD(H) levels predict clonal lymphocyte expansion dynamics

A bstract. Adaptive immunity requires the expansion of high-affinity lymphocytes from a heterogeneous pool. Whereas current models explain this through signal transduction, we hypothesized that…

UmiWellDecember 30, 2024

DNA Repair

Toll/interleukin-1 receptor (TIR) domain-containing proteins have NAD-RNA decapping activity

A bstract. The occurrence of NAD+ as a non-canonical RNA cap has been demonstrated in diverse organisms. TIR domain-containing proteins present in all kingdoms of life…

UmiWellDecember 30, 2024

Cellular Repair DNA Repair

NMNAT2 is a druggable target to drive neuronal NAD production

A bstract. Maintenance of NAD pools is critical for neuronal survival. The capacity to maintain NAD pools declines in neurodegenerative disease. We identify that low…

UmiWellDecember 30, 2024

DNA Repair

NAD+ Boosts Mitochondria and Stem Cells, Extends Lifespan

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UmiWellApril 29, 2024

DNA Repair

Reversible Vascular Aging via NAD+-H2S Disruption

A bstract The study finds that NAD precursors can reverse certain aspects of aging by activating sirtuin deacylases (SIRT1-SIRT7), which also mediate the benefits of…

UmiWellMarch 22, 2024

DNA Repair Post Trans-Protein

Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival

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UmiWellJanuary 10, 2024

DNA Repair

NAD+ Precursor Prevents Kidney Injury Inflammation

A bstract Our understanding of how global changes in cellular metabolism contribute to human kidney disease remains incompletely understood. Here we show that nicotinamide adenine…

UmiWellJanuary 8, 2024